GENESIS combines two highly developed procedures, IVF and PGT-A, to even further ensure, if possible, the health of our patients' newborn babies. We are passionate about patient care, thus we offer you the opportunity to join two demanded procedures on favorable terms.

What is IVF Genetic?

IVF Genetic is a combination of In Vitro Fertilisation (IVF) and Preimplantation Genetic Testing (PGT-A), which is aimed at detecting abnormalities of the number of chromosomes in embryos.

PGT-A allows for screening the embryos obtained during IVF or ICSI and identify possible cases of incorrect number of chromosomes resulting either in a miscarriage or in significant genetic syndromes. Such conditions include Down syndrome (trisomy 21), Edwards syndrome (trisomy 18), Patau syndrome (trisomy 13) and common sex chromosome aneuploidies, for instance, Turner and Klinefelter syndromes.

A 2011 research has found that Klinefelter syndrome incidence amounts to 1 in 600 men, while Down syndrome affects 1 in 700 babies in the US. Thus, in response to our patients' growing concern for the health of their future babies, our Center combines two procedures making them possibly available.

Recommendations

We may recommend you to perform PGT-A following IVF in the following cases:

• Women at the age of 35 or higher (maternal age has been linked to an increased probability of having a baby with Down syndrome);
• Women who have had two or more failed ART cycles;
• Women who have experienced two or more miscarriages due to unknown causes;
• Women who have had previous pregnancies with chromosomal abnormalities, especially during ART cycles;
• Men with a low sperm count or with sperm known for incorrect meiosis.

IVF Genetic vs conventional IVF

PGT-A is a technique that detects numerical abnormalities in the embryo chromosomes. Accordingly, IVF Genetic boosts chances to have a successful pregnancy and a healthy child. Compared to conventional IVF, the combined procedure ensures:

• Increased implantation rate of embryos and consequently, higher probability of getting pregnant;
• Lower risk of miscarriage;
• Increased chances of having a healthy baby;
• Lower probability of going through multiple cycles.

Success rates

IVF Genetic provides for greater pregnancy rates than conventional IVF. The embryos chosen for transfer during the screening do not bear aneuploidy and also have the best morphology. Thus, cumulative delivery rate reaches 64%.

Pregnancy probability depends, in every individual case, on various factors: age, ovarian reserve, medical and reproductive history, etc. And no matter what your history is, our fertility specialists will design the appropriate treatment plan and provide access to proven modern technologies to make you a parent.

Our pregnancy rates are audited by RAHR, an accredited body to monitor and update the data on reproduction clinics performance.

Procedure

1. First visit

Your first visit to the Center is the starting point of the way that leads to becoming a parent. At this stage, our fertility specialists will study and analyze your medical record and conduct a gynecological examination and a sperm analysis in the case of heterosexual couples. You will receive a personalized diagnosis and thereby will be able to choose treatment on a rational basis.

2. Ovarian stimulation

This stage is needed to harvest multiple mature eggs instead of one that month and thereby produce more embryos. You will need to self-administer daily injections of hormone medications for 15-25 days to boost the development of eggs in the ovaries.

This stage of treatment can be carried out at the place of your residence, by your gynecologist, using ultrasound scans (3 or 4) and blood tests to thoroughly monitor the stimulation. A dose of the hCG hormone will be administered upon the reaching the right number and size of follicles. The hormone induces ovulation, and 36 hours later, GENESIS conducts an intrauterine insemination.

3. Egg collection

The mature eggs are retrieved through transvaginal ultrasound aspiration. During this procedure, an ultrasound probe will be inserted into your vagina to identify follicles, and a thin needle will be guided through the vagina and into the follicles. To collect eggs, our specialists will need to puncture every follicle and aspirate the fluids containing the oocytes.

The procedure takes less than 15-20 minutes and soon after, our embryologist will tell you how many eggs were retrieved.

If you live in another country, you can return the very same day and resume everyday tasks.

4. In vitro fertilisation

When the eggs and sperm sample are procured, our medical team may proceed with fertilization.

During the procedure, an egg and sperm are manually combined in a laboratory dish.

5. Embryo culture

At this stage, the development of the fertilized eggs is daily monitored so that our laboratory specialists can classify them according to their quality and select one to transfer into the uterus.

6. Embryo vitrification and PGT-A

To gather the necessary genetic material for analysis, the approved embryos are biopsied, which involves producing a tiny opening to extract a few cells. Following the biopsy, the embryos are vitrified (frozen in liquid nitrogen) until the results of the genetic screening become available.

The biopsied cells undergo the PGT-A to examine the number of chromosomes in the embryos. The technology applied to carry out the test is called NGS (next-generation sequencing, or massive parallel sequencing) and allows for throughput, speed, and scalability at an ultra-high level.

Over 10 days, the results are received. Only embryos with confirmed correct number of chromosomes become candidates for devitrification and transfer into the mother's uterus.

7. Transfer of the best embryo

Prior to the transfer, the mother's uterus must be prepared to ensure that the inner layer of the uterus, called endometrium, has the appropriate thickness to receive the embryo and facilitate gestation.

On transfer day, one of the embryos classified as healthy will be thawed and introduced into the mother's uterus by inserting an embryo transfer catheter vaginally. The procedure is painless and  requires no anaesthesia. After a short rest, you  may resume everyday activity.

8. Pregnancy test

Blood pregnancy test to confirm pregnancy is to be taken typically 11 days after the transfer. If the result is positive, 20 days later you will undergo a control ultrasound scan. If you live in another country, you can return home after this stage.